A simple, precise, accurate and economical UV visible spectrophotometric method has been developed for estimation of acebutolol hydrochloride drug by AUC method. The standard and sample solutions were prepared by using double distilled water as a solvent. Quantitative determination of the drug was performed at wavelength range 226-240 nm. The linearity was established over the concentration range of 05-25 µg/ml for acebutolol hydrochloride with correlation coefficient value of 0.9985. Precisionstudies showed that % relative standard deviation was within range ofacceptable limits. The mean percentage recovery was found to be 99.39%. The proposed method has been validated as per ICH guidelines.
Loading....